Journal: Journal of Clinical Microbiology
Article Title: Comparison of the Results of Five SARS-CoV-2 Antibody Assays before and after the First and Second ChAdOx1 nCoV-19 Vaccinations among Health Care Workers: a Prospective Multicenter Study
doi: 10.1128/JCM.01788-21
Figure Lengend Snippet: Quantitative serological responses before and after the first and second doses of the AstraZeneca vaccine according to the Roche total Ab (A), Abbott IgG (B), Siemens IgG (C), SD Biosensor V1 neutralizing antibody (D), SD Biosensor V2 neutralizing antibody (E), and GenScript neutralizing antibody (F) assays. P values were calculated using the Kruskal-Wallis test for the quantitative differences between before and after the first and second vaccinations. The differences among the results at baseline and after the first and second vaccinations for all included assays were significant ( P < 0.001). The cutoff for each assay is shown as a dashed line.
Article Snippet: The median values of the Roche, Abbott IgG, Siemens IgG, SD Biosensor V1, SD Biosensor V2, and GenScript assay results in the samples after the second dose were 830.0 U/ml, 1,003.7 AU/ml, 10.8 index, 99.5%, 97.4%, and 88.0%, respectively, which showed that the second dose of vaccination led to a significant increase of 106.4-fold for Roche total antibody, 3.6-fold for Abbott IgG, 3.6-fold for Siemens, 1.2-fold for SD Biosensor V1 neutralizing antibody, 1.9-fold for SD Biosensor V2 neutralizing antibody, and 2.2-fold for GenScript neutralizing antibody compared to the first dose ( ).
Techniques: